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Article

TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2015

Haricharan Svasti, Brown Powel

Abstract excerpt

Breast cancer is a leading cause of cancer-related death, and it is important to understand pathways that drive the disease to devise effective therapeutic strategies. Our results show that Toll-like receptor 4 (TLR4) drives breast cancer cell growth differentially based on the presence of TP53, a tumor suppressor. TP53 is mutationally inactivated in most types of cancer and is mutated in 30-50% of diagnosed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-gamma

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Source

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Identifiers

PMID: 26063617
DOI: 10.1073/pnas.1420811112
PMCID: PMC4485113

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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