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p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus

22 Aug 2019

Abstract excerpt

The Toll-like receptor 8 (TLR8) has an important role in innate immune responses to RNA viral infections, including respiratory syncytial virus (RSV). We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis. Because this SNP is in...

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PMID: 31430261
DOI: 10.1172/jci128626

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