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Article

The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.

Cancer research - 15 Aug 2012

Shatz Maria, Menendez Daniel, Resnick Michael A

Abstract excerpt

The transcription factor p53 regulates genes associated with a wide range of functions, including the Toll-like receptor (TLR) set of innate immunity genes, suggesting that p53 also modulates the human immune response. The TLR family comprises membrane glycoproteins that recognize pathogen-associated molecular patterns (PAMP) and mediate innate immune responses, and TLR agonists are being used as adjuvants in...

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Identifiers

PMID: 22673234
DOI: 10.1158/0008-5472.CAN-11-4134
PMCID: PMC3443562

Genes

TLR3
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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