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Article

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.

PLoS genetics - 1 Mar 2011

Menendez Daniel, Shatz Maria, Azzam Kathleen, Garantziotis Stavros, Fessler Michael B, Resnick Michael A

Abstract excerpt

In recent years the functions that the p53 tumor suppressor plays in human biology have been greatly extended beyond "guardian of the genome." Our studies of promoter response element sequences targeted by the p53 master regulatory transcription factor suggest a general role for this DNA damage and stress-responsive regulator in the control of human Toll-like receptor (TLR) gene expression. The TLR gene family...

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Topics

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Share to DNA Damage
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Lymphocytes

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Share to Stress, Physiological

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Source

Open in PubMed Open full text

Identifiers

PMID: 21483755
DOI: 10.1371/journal.pgen.1001360
PMCID: PMC3069118

Genes

TLR1
TLR10
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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