Article
Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population.
Drug and alcohol dependence - 1 Oct 2016
Otto Jacqueline M, Gizer Ian R, Bizon Chris, Wilhelmsen Kirk C, Ehlers Cindy L
Abstract excerpt
BACKGROUND: Recent studies have demonstrated the utility of polygenic risk scores (PRSs) for exploring the genetic etiology of psychiatric phenotypes and the genetic correlations between them. To date, these studies have been conducted almost exclusively using participants of European ancestry, and thus, there is a need for similar studies conducted in other ancestral populations. However, given that the...
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