Article
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
Psychological medicine - 20 Aug 2025
Johnson Emma C, Lai Dongbing, Balbona Jared V, Miller Alex P, Hatoum Alexander S, Deak Joseph D, Jennings Mariela, Baranger David A A, Galimberti Marco, Sanichwankul Kittipong, Thorgeirsson Thorgeir, Colbert Sarah M C, Adhikari Keyrun, Docherty Anna R, Degenhardt Louisa, Edwards Tobias, Fox Louis, Giannelis Alexandros, Jeffries Paul W, Korhonen Tellervo, Morrison Claire L, Nunez Yaira Z, Palviainen Teemu, Su Mei-Hsin, Romero Villela Pamela N, Wetherill Leah, Willoughby Emily A, Zellers Stephanie M, Bierut Laura J, Buchwald Jadwiga, Copeland William E, Corley Robin P, Friedman Naomi P, Foroud Tatiana M, Gillespie Nathan A, Gizer Ian R, Heath Andrew C, Hickie Ian B, Kaprio Jaakko, Keller Matthew C, Lee James J, Lind Penelope, Madden Pamela A, Maes Hermine H M, Martin Nicholas G, McGue Matt, Medland Sarah E, Nelson Elliot C, Pearson John, Porjesz Bernice, Stallings Michael C, Vrieze Scott, Wilhelmson Kirk C, Kranzler Henry R, Walters Raymond K, Polimanti Renato, Malison Robert, Zhou Hang, Stefansson Kari, Sanchez-Roige Sandra, Potenza Marc, Mutirangura Apiwat, Shotelersuk Vorasuk, Kalayasiri Rasmon, Edenberg Howard J, Gelernter Joel, Agrawal Arpana
Abstract excerpt
BACKGROUND: Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. METHODS: We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared...
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