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Article

Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals.

Addiction biology - 1 Jan 2022

Hartwell Emily E, Merikangas Alison K, Verma Shefali S, Ritchie Marylyn D, Kranzler Henry R, Kember Rachel L

Abstract excerpt

Polygenic risk scores (PRS) represent an individual's summed genetic risk for a trait and can serve as biomarkers for disease. Less is known about the utility of PRS as a means to quantify genetic risk for substance use disorders (SUDs) than for many other traits. Nonetheless, the growth of large, electronic health record-based biobanks makes it possible to evaluate the association of SUD PRS with other traits....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34611967
DOI: 10.1111/adb.13099
PMCID: PMC9254745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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