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Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour.

Drug and alcohol dependence - 1 Oct 2024

Foo Jerome C, Völker Maja P, Streit Fabian, Frank Josef, Zacharias Norman, Zillich Lea, Sirignano Lea, Nürnberg Peter, Wienker Thomas F, Wagner Michael, Nöthen Markus M, Nothnagel Michael, Walter Henrik, Lenz Bernd, Spanagel Rainer, Kiefer Falk, Winterer Georg, Rietschel Marcella, Witt Stephanie H

Abstract excerpt

INTRODUCTION: Formal genetics studies show that smoking is influenced by genetic factors; exploring this on the molecular level can offer deeper insight into the etiology of smoking behaviours. METHODS: Summary statistics from the latest wave of the GWAS and Sequencing Consortium of Alcohol and Nicotine (GSCAN) were used to calculate polygenic risk scores (PRS) in a sample of ~2200 individuals who...

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PMID: 39197361
DOI: 10.1016/j.drugalcdep.2024.112415

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SI

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