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Article

Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease.

Kidney international - 1 Oct 2016

Cejka Daniel, Parada-Rodriguez Diego, Pichler Stefanie, Marculescu Rodrig, Kramer Ina, Kneissel Michaela, Gross Thomas, Reisinger Andreas, Pahr Dieter, Monier-Faugere Marie-Claude, Haas Martin, Malluche Hartmut H

Abstract excerpt

Renal osteodystrophy affects the majority of patients with advanced chronic kidney disease (CKD) and is characterized by progressive bone loss. This study evaluated the effects of sclerostin knockout on bone in a murine model of severe, surgically induced CKD in both sclerostin knockout and wild-type mice. Mice of both genotypes with normal kidney function served as controls. Tibiae were analyzed using...

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Identifiers

PMID: 27528549
DOI: 10.1016/j.kint.2016.06.019
PMCID: PMC5530366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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