Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.

doi:10.1359/jbmr.080216

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Article

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2008

Li Xiaodong, Ominsky Michael S, Niu Qing-Tian, Sun Ning, Daugherty Betsy, D'Agostin Diane, Kurahara Carole, Gao Yongming, Cao Jin, Gong Jianhua, Asuncion Frank, Barrero Mauricio, Warmington Kelly, Dwyer Denise, Stolina Marina, Morony Sean, Sarosi Ildiko, Kostenuik Paul J, Lacey David L, Simonet W Scott, Ke Hua Zhu, Paszty Chris

Abstract excerpt

INTRODUCTION: Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations in SOST, the gene encoding sclerostin. Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone. MATERIALS AND METHODS: Gene targeting was used to...

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PMID: 18269310
DOI: 10.1359/jbmr.080216

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SOST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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