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Article

Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013

Ryan Zachary C, Ketha Hemamalini, McNulty Melissa S, McGee-Lawrence Meghan, Craig Theodore A, Grande Joseph P, Westendorf Jennifer J, Singh Ravinder J, Kumar Rajiv

Abstract excerpt

Inactivating mutations of the SOST (sclerostin) gene are associated with overgrowth and sclerosis of the skeleton. To determine mechanisms by which increased amounts of calcium and phosphorus are accreted to enable enhanced bone mineralization in the absence of sclerostin, we measured concentrations of calciotropic and phosphaturic hormones, and urine and serum calcium and inorganic phosphorus in mice in which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23530237
DOI: 10.1073/pnas.1221255110
PMCID: PMC3625358

Genes

SOST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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