Article
Role of sclerostin in the pathogenesis of chronic kidney disease-mineral bone disorder
2016-02-17
Abstract excerpt
Sclerostin is a 190-amino-acid glycoprotein that is mainly secreted by osteocytes, and it decreases bone formation by inhibiting the terminal differentiation of osteoblasts and promoting their apoptosis. Sclerostin blocks the Wnt signaling pathway in osteoblasts by binding to low-density lipoprotein receptor-related protein 5/6 (LRP-5/6) receptors. We reviewed the literature detailing the role of sclerostin in the...
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Identifiers and source
- Literature Corpus work
- 033aa6c2-9089-5628-95e6-13df2430b2f8
- DOI
- 10.1186/s41100-016-0024-4