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Article

The combination of aging and chronic kidney disease leads to an exacerbated cortical porosity phenotype.

Bone - 1 Jan 2022

Tippen Samantha P, Metzger Corinne E, Swallow Elizabeth A, Sacks Spencer A, Wallace Joseph M, Allen Matthew R

Abstract excerpt

PURPOSE: Chronic kidney disease (CKD) and aging are each independently associated with higher fracture risk. Although CKD is highly prevalent in the aging population, the interaction between these two conditions with respect to bone structure and mechanics is not well understood. The purpose of this study was to examine cortical porosity and mechanical properties in skeletally mature young and aging mice with...

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Identifiers

PMID: 34624561
DOI: 10.1016/j.bone.2021.116228
PMCID: PMC8671241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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