Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.

doi:10.1002/jbmr.1630

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2012

Sabbagh Yves, Graciolli Fabiana Giorgeti, O'Brien Stephen, Tang Wen, dos Reis Luciene Machado, Ryan Susan, Phillips Lucy, Boulanger Joseph, Song Wenping, Bracken Christina, Liu Shiguang, Ledbetter Steven, Dechow Paul, Canziani Maria Eugenia F, Carvalho Aluizio B, Jorgetti Vanda, Moyses Rosa M A, Schiavi Susan C

Abstract excerpt

Chronic kidney disease-mineral bone disorder (CKD-MBD) is defined by abnormalities in mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of soft-tissue calcification. Emerging evidence suggests that features of CKD-MBD may occur early in disease progression and are associated with changes in osteocyte function. To identify early changes in bone, we utilized the jck mouse, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Remodeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcification, Physiologic

Share to Cardiovascular Abnormalities

Share to NIMA-Related Kinases

Share to Osteoclasts

Share to Osteocytes

Share to Vascular Calcification

Share to Wnt Signaling Pathway

Source

Open in PubMed

Identifiers

PMID: 22492547
DOI: 10.1002/jbmr.1630

Genes

SOST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.PMID 22492547Read ↗

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone HomeostasisSemantic proximity Read ↗

New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosisSemantic proximity Read ↗

Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease.Semantic proximity Read ↗

Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney DiseaseSemantic proximity Read ↗

Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney diseaseSemantic proximity Read ↗

Wnt/β-catenin signaling: A novel target for therapeutic intervention of fibrotic kidney diseaseSemantic proximity Read ↗

Canonical Notch activation in osteocytes causes osteopetrosisSemantic proximity Read ↗

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.Semantic proximity Read ↗

Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover.Semantic proximity Read ↗

Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2Semantic proximity Read ↗

Calcineurin A-alpha but not A-beta is required for normal kidney development and function.Semantic proximity Read ↗

c-Met and NF-κB–Dependent Overexpression of Wnt7a and -7b and Pax2 Promotes Cystogenesis in Polycystic Kidney DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.