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Article

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.

Molecular psychiatry - 1 Apr 2017

Keller J, Gomez R, Williams G, Lembke A, Lazzeroni L, Murphy G M, Schatzberg A F

Abstract excerpt

The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis genetic variation in cognition. The present study investigated the simultaneous roles HPA axis...

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Source

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Identifiers

PMID: 27528460
DOI: 10.1038/mp.2016.120
PMCID: PMC5313380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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