Genetic and epigenetic changes to the glucocorticoid receptor gene (NR3C1) and cognition in major depressive disorder.

doi:10.1016/j.sjpmh.2024.12.002

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Article

Genetic and epigenetic changes to the glucocorticoid receptor gene (NR3C1) and cognition in major depressive disorder.

Spanish journal of psychiatry and mental health - 1 Jan 2026

Ferrer Alex, Labad Javier, Salvat-Pujol Neus, Urretavizcaya Mikel, Obrador-Font Roser, Menchón José M, Palao Diego, Soriano-Mas Carles, Costas Javier, Barrachina Marta, Carracedo Ángel, Soria Virginia

Abstract excerpt

INTRODUCTION: Many studies have found that hypothalamic-pituitary-adrenal (HPA) axis abnormalities are related to the pathophysiology of major depressive disorder (MDD) and cognitive functioning. Our aim was to assess the influence of genetic polymorphisms and methylation levels in three different promoter regions throughout the glucocorticoid receptor (GR) gene NR3C1 on cognitive performance in MDD. Plausible...

Read the complete abstract on PubMed

Topics

Humans
Receptors, Glucocorticoid
Major Depressive Disorder
Female
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Epigenesis, Genetic

Male

DNA Methylation

Adult

Executive Function

Memory, Short-Term

Young Adult

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 40189105
DOI: 10.1016/j.sjpmh.2024.12.002

Genes

NR3C1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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