Article

Neurocognitive deficits, psychotrauma, and inflammation shape major depressive disorder and its phenome features

2026-02-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Major depressive disorder (MDD) involves immune–metabolic dysregulation, psychosocial adversity, and multidomain cognitive disturbances, yet single cognitive indices often show small and inconsistent effects. We derived a multivariate Cambridge Neuropsychological Test Automated Battery (CANTAB)-based cognitive phenotype (“cognitype”) and tested whether it adds explanatory va...

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Literature Corpus work: eeee0ec7-ea5f-5ed3-a75d-7589415596a6
DOI: 10.64898/2026.02.11.26346056

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