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Neurocognitive deficits, psychotrauma, and inflammation shape major depressive disorder and its phenome features.

Journal of affective disorders - 1 Sept 2026

Wang Xueyan, Wang Ping, Niu Mengqi, Yangyang Chengkai, Almulla Abbas F, Chen Chen, Li Jing, Zhang Yingqian, Maes Michael

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) involves immune-metabolic dysregulation, psychosocial adversity, and multidomain cognitive disturbances, yet single cognitive indices often show small and inconsistent effects. We derived a multivariate Cambridge Neuropsychological Test Automated Battery (CANTAB)-based cognitive phenotype ("cognitype") and tested whether it adds explanatory value beyond adverse...

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PMID: 42031014
DOI: 10.1016/j.jad.2026.121840

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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