Article
Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis.
Disease models & mechanisms - 1 Oct 2016
Hansen Sarah A, Hart Marcia L, Busi Susheel, Parker Taybor, Goerndt Angela, Jones Kevin, Amos-Landgraf James M, Bryda Elizabeth C
Abstract excerpt
Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulate human disease are important for drug discovery, biomarker development and disease modeling. Current Tp53 mouse and...
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