Article
Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.
Bone - 1 Jul 2013
Mutsaers Anthony J, Ng Alvin J M, Baker Emma K, Russell Megan R, Chalk Alistair M, Wall Meaghan, Liddicoat Brain J J, Ho Patricia W M, Slavin John L, Goradia Ankita, Martin T John, Purton Louise E, Dickins Ross A, Walkley Carl R
Abstract excerpt
Osteosarcoma is the most common primary cancer of bone and one that predominantly affects children and adolescents. Osteoblastic osteosarcoma represents the major subtype of this tumor, with approximately equal representation of fibroblastic and chondroblastic subtypes. We and others have previously described murine models of osteosarcoma based on osteoblast-restricted Cre:lox deletion of Trp53 (p53) and Rb1...
Topics
- Animals
- Biomarkers, Tumor
- Cell Differentiation
- Cell Lineage
- Cell Membrane
- Chromosomes, Mammalian
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Gene Knockdown Techniques