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Article

Lack of major genome instability in tumors of p53 null rats.

PloS one - 1 Jan 2015

Hermsen Roel, Toonen Pim, Kuijk Ewart, Youssef Sameh A, Kuiper Raoul, van Heesch Sebastiaan, de Bruin Alain, Cuppen Edwin, Simonis Marieke

Abstract excerpt

Tumorigenesis is often associated with loss of tumor suppressor genes (such as TP53), genomic instability and telomere lengthening. Previously, we generated and characterized a rat p53 knockout model in which the homozygous rats predominantly develop hemangiosarcomas whereas the heterozygous rats mainly develop osteosarcomas. Using genome-wide analyses, we find that the tumors that arise in the heterozygous and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25811670
DOI: 10.1371/journal.pone.0122066
PMCID: PMC4374866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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