Article
Tumor spectrum analysis in p53-mutant mice.
Current biology : CB - 1 Jan 1994
Jacks T, Remington L, Williams B O, Schmitt E M, Halachmi S, Bronson R T, Weinberg R A
Abstract excerpt
BACKGROUND: The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one mutant allele of p53 are susceptible to a wide range of tumor types. The gene encodes a transcriptional regulator that may function in the cellular response to DNA damage. The construction of mouse strains carrying germline mutations...
Topics
- Alleles
- Animals
- Base Sequence
- Chimera
- Chromosome Deletion
- Crosses, Genetic
- DNA Damage
- DNA Primers
- Female
- Genes, p53
- Humans
- Li-Fraumeni Syndrome