Article
Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.
The American journal of pathology - 1 Oct 2011
van Boxtel Ruben, Kuiper Raoul V, Toonen Pim W, van Heesch Sebastiaan, Hermsen Roel, de Bruin Alain, Cuppen Edwin
Abstract excerpt
The TP53 tumor suppressor gene is mutated in the majority of human cancers. Inactivation of p53 in a variety of animal models results in early-onset tumorigenesis, reflecting the importance of p53 as a gatekeeper tumor suppressor. We generated a mutant Tp53 allele in the rat using a target-selected mutagenesis approach. Here, we report that homozygosity for this allele results in complete loss of p53 function....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.