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Defining function of wild-type and patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

2021-04-22

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In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss or gain of function TP53 mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding TP53 effects on tumorigenesis remains central to realizing better treatment outcomes. In ERMS, >70% of patients retain wild-type TP53 , yet TP53 mutations when presen...

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Literature Corpus work: 68f7e018-97b0-5c8b-b953-65949c06ee2d
DOI: 10.1101/2021.04.21.440757

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Defining function of wild-type and patient specific <i>TP53</i> mutations in a zebrafish model of embryonal rhabdomyosarcoma

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