Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

7 Sept 2018

Abstract excerpt

The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive Natural Killer cell-like leukemia for which no animal model has been developed. Because the tp53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30192230
DOI: 10.7554/elife.37202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafishPMID 30192230Read ↗

Defining function of wild-type and patient specific <i>TP53</i> mutations in a zebrafish model of embryonal rhabdomyosarcomaSemantic proximity Read ↗

Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma.Semantic proximity Read ↗

p53 Pathway Inactivation Drives SMARCB1 -deficient p53 -wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 InhibitionSemantic proximity Read ↗

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.Semantic proximity Read ↗

Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis.Semantic proximity Read ↗

A syngeneic spontaneous zebrafish model of <i>tp53</i> -deficient, EGFR <sup>vIII</sup> , and PI3KCA <sup>H1047R</sup> -driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse <i>in vivo</i>Semantic proximity Read ↗

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)Semantic proximity Read ↗

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applicationsSemantic proximity Read ↗

Histologic and Immunohistochemical Analyses of Soft Tissue Sarcomas From brca2-Mutant/ tp53-Mutant Zebrafish Are Consistent With Neural Crest (Schwann Cell) Origin.Semantic proximity Read ↗

<i>tp53</i> R217H and R242H Mutant Zebrafish Exhibit Dysfunctional p53 Hallmarks and Recapitulate Li-Fraumeni Syndrome PhenotypesSemantic proximity Read ↗

Genetic modeling of Li-Fraumeni syndrome in zebrafish.Semantic proximity Read ↗

You can win by losing: p53 mutations in rhabdomyosarcomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.