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Article

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.

The Journal of clinical investigation - 1 Sept 2016

Miyazaki Takuro, Tonami Kazuo, Hata Shoji, Aiuchi Toshihiro, Ohnishi Koji, Lei Xiao-Feng, Kim-Kaneyama Joo-Ri, Takeya Motohiro, Itabe Hiroyuki, Sorimachi Hiroyuki, Kurihara Hiroki, Miyazaki Akira

Abstract excerpt

Macrophages contribute to the development of atherosclerosis through pinocytotic deposition of native LDL-derived cholesterol in macrophages in the vascular wall. Inhibiting macrophage-mediated lipid deposition may have protective effects in atheroprone vasculature, and identifying mechanisms that potentiate this process may inform potential therapeutic interventions for atherosclerosis. Here, we report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27525442
DOI: 10.1172/JCI85880
PMCID: PMC5004959

Genes

CAPN6
CWC22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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