Article
Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders.
Journal of atherosclerosis and thrombosis - 1 Jan 2018
Miyazaki Takuro, Miyazaki Akira
Abstract excerpt
Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death in vascular/immune cells, remodeling of extracellular matrix or breakdown of elastic lamella. Increasing evidence...
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