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Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages

23 Oct 2020

Abstract excerpt

The loss of efferocytosis – the phagocytic clearance of apoptotic cells – is an initiating event in atherosclerotic plaque formation. While the loss of macrophage efferocytosis is a prerequisite for advanced plaque formation, the transcriptional and cellular events in the pre-lesion site that drive these defects are poorly defined. Transcriptomic analysis of macrophages recovered from early-stage human...

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PMID: 33193444
DOI: 10.3389/fimmu.2020.594136

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