Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner.

doi:10.1016/j.atherosclerosis.2018.06.015

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Article

Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner.

Atherosclerosis - 1 Aug 2018

Amersfoort J, Schaftenaar F H, Douna H, van Santbrink P J, Kröner M J, van Puijvelde G H M, Quax P H A, Kuiper J, Bot I

Abstract excerpt

BACKGROUND AND AIMS: Lipocalin-2 (Lcn2) is a glycoprotein which can be secreted by immune cells. Several studies in humans have suggested Lcn2 can be used as a biomarker for the detection of unstable atherosclerotic lesions, partly as it is known to interact with MMP-9. METHODS: In this study, we generated Ldlr-/-Lcn2-/- mice to assess the functional role of Lcn2 in different stages of atherosclerosis....

Topics

Animals
Aorta
Aortic Diseases
Atherosclerosis
Diet, High-Fat
Disease Models, Animal
Disease Progression
Female
Genetic Predisposition to Disease
Lipocalin-2
Matrix Metalloproteinase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Monocytes

Necrosis

Phenotype

Plaque, Atherosclerotic

Receptors, LDL

Time Factors

Source

Open in PubMed

Identifiers

PMID: 29960897
DOI: 10.1016/j.atherosclerosis.2018.06.015

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