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Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis

24 Apr 2019

Abstract excerpt

Background: The actin-binding protein FLNA (filamin A) regulates signal transduction important for cell locomotion, but the role of macrophage-specific FLNA during atherogenesis has not been explored. Methods: We analyzed FLNA expression in human carotid atherosclerotic plaques by immunofluorescence. We also produced mice with Flna -deficient macrophages by breeding conditional Flna -knockout mice ( Flna o/fl )...

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PMID: 31014088
DOI: 10.1161/circulationaha.119.039697

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