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Article

Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice.

Gastroenterology - 1 Dec 2016

Yamaguchi Junpei, Mino-Kenudson Mari, Liss Andrew S, Chowdhury Sanjib, Wang Timothy C, Fernández-Del Castillo Carlos, Lillemoe Keith D, Warshaw Andrew L, Thayer Sarah P

Abstract excerpt

BACKGROUND & AIMS: Little is known about the origin of pancreatic intraductal papillary mucinous neoplasms (IPMN). Pancreatic duct glands (PDGs) are gland-like outpouches budding off the main pancreatic ducts that function as a progenitor niche for the ductal epithelium; they express gastric mucins and have characteristics of side-branch IPMNs. We investigated whether PDGs are a precursor compartment for IPMNs...

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Source

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Identifiers

PMID: 27523981
DOI: 10.1053/j.gastro.2016.07.045
PMCID: PMC5396548

Genes

TFF2
SMAD4
MUC2
TFF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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