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Loss of HNF1B drives pancreatic Intraductal Papillary and Mucinous Neoplasms (IPMN) initiation

2025-06-17

Abstract excerpt

<h4>Background</h4> Intraductal papillary mucinous neoplasms (IPMNs) are clinically detectable precursors of pancreatic adenocarcinoma, yet the mechanisms initiating their development remain poorly defined. Although KRAS mutations are highly frequent in human IPMNs, KRAS activation in pancreatic ductal cells alone fails to recapitulate IPMN development in murine models, indicating that additional tumor-suppressiv...

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Literature Corpus work
dde001e4-5327-5522-b330-c3e3d223e67d
DOI
10.1101/2025.06.12.659269
Open publication

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