Article
Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2.
Gastroenterology - 1 Nov 2020
DelGiorno Kathleen E, Chung Chi-Yeh, Vavinskaya Vera, Maurer H Carlo, Novak Sammy Weiser, Lytle Nikki K, Ma Zhibo, Giraddi Rajshekhar R, Wang Dezhen, Fang Linjing, Naeem Razia F, Andrade Leonardo R, Ali Wahida H, Tseng Hubert, Tsui Crystal, Gubbala Vikas B, Ridinger-Saison Maya, Ohmoto Makoto, Erikson Galina A, O'Connor Carolyn, Shokhirev Maxim Nikolaievich, Hah Nasun, Urade Yoshihiro, Matsumoto Ichiro, Kaech Susan M, Singh Pankaj K, Manor Uri, Olive Kenneth P, Wahl Geoffrey M
Abstract excerpt
BACKGROUND & AIMS: Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells because of the lack of animal models. We investigated the role of tuft cells in pancreatic tumorigenesis. METHODS: We performed studies with LSL-KrasG12D/+;Ptf1aCre/+ mice (KC; develop pancreatic tumors), KC mice crossed with...
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