Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

doi:10.1016/j.ajpath.2012.02.006

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Article

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

The American journal of pathology - 1 Jun 2012

Vincent David F, Gout Johann, Chuvin Nicolas, Arfi Vanessa, Pommier Roxane M, Bertolino Philippe, Jonckheere Nicolas, Ripoche Doriane, Kaniewski Bastien, Martel Sylvie, Langlois Jean-Baptiste, Goddard-Léon Sophie, Colombe Amélie, Janier Marc, Van Seuningen Isabelle, Losson Régine, Valcourt Ulrich, Treilleux Isabelle, Dubus Pierre, Bardeesy Nabeel, Bartholin Laurent

Abstract excerpt

Transcriptional intermediary factor 1γ (TIF1γ; alias, TRIM33/RFG7/PTC7/ectodermin) belongs to an evolutionarily conserved family of nuclear factors that have been implicated in stem cell pluripotency, embryonic development, and tumor suppression. TIF1γ expression is markedly down-regulated in human pancreatic tumors, and Pdx1-driven Tif1γ inactivation cooperates with the Kras(G12D) oncogene in the mouse pancreas...

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Identifiers

PMID: 22469842
DOI: 10.1016/j.ajpath.2012.02.006
PMCID: PMC3378851

Genes

SMAD4
TRIM33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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