Article
Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms.
The Journal of pathology - 1 Nov 2020
Huang Bo, Trujillo Maria A, Fujikura Kohei, Qiu Miaozhen, Chen Fei, Felsenstein Matthäus, Zhou Cancan, Skaro Michael, Gauthier Christian, Macgregor-Das Anne, Hutchings Danielle, Hong Seung-Mo, Hruban Ralph H, Eshleman James R, Thompson Elizabeth D, Klein Alison P, Goggins Michael, Wood Laura D, Roberts Nicholas J
Abstract excerpt
Intraductal papillary mucinous neoplasms (IPMNs) are commonly identified non-invasive cyst-forming pancreatic neoplasms with the potential to progress into invasive pancreatic adenocarcinoma. There are few in vitro models with which to study the biology of IPMNs and their progression to invasive carcinoma. Therefore, we generated a living biobank of organoids from seven normal pancreatic ducts and ten IPMNs. We...
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