Article
Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice.
Gastroenterology - 1 Apr 2018
Kopp Janel L, Dubois Claire L, Schaeffer David F, Samani Atefeh, Taghizadeh Farnaz, Cowan Robert W, Rhim Andrew D, Stiles Bangyan L, Valasek Mark, Sander Maike
Abstract excerpt
BACKGROUND & AIMS: Intraductal papillary mucinous neoplasias (IPMNs) are precancerous cystic lesions that can develop into pancreatic ductal adenocarcinomas (PDACs). These large macroscopic lesions are frequently detected during medical imaging, but it is unclear how they form or progress to PDAC. We aimed to identify cells that form IPMNs and mutations that promote IPMN development and progression. METHODS: We...
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