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KrasandLkb1mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells

1 Jun 2019

Abstract excerpt

Objective Pancreatic cancer can arise from precursor lesions called intraductal papillary mucinous neoplasms (IPMN), which are characterised by cysts containing papillae and mucus-producing cells. The high frequency ofKRASmutations in IPMN and histological analyses suggest that oncogenic KRAS drives IPMN development from pancreatic duct cells. However, induction ofKrasmutation in ductal cells is not sufficient to...

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PMID: 31154393
DOI: 10.1136/gutjnl-2018-318059

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