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Article

Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage.

Journal of translational medicine - 12 Aug 2016

Canossi Angelica, Aureli Anna, Del Beato Tiziana, Rossi Piero, Franceschilli Luana, De Sanctis Flavio, Sileri Pierpaolo, di Lorenzo Nicola, Buonomo Oreste, Lauro Davide, Venditti Adriano, Sconocchia Giuseppe

Abstract excerpt

BACKGROUND: NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding affinity of the Fcγ receptor IIIA (CD16A) for IgG-coated tumor cells. Thus, it is conceivable that KIR and CD16A gene contents may contribute to the function of NK cells by modulating an immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27519478
DOI: 10.1186/s12967-016-1001-y
PMCID: PMC4983069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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