Article
The influence of NK cell-mediated ADCC: Structure and expression of the CD16 molecule differ among FcγRIIIa-V158F genotypes in healthy Japanese subjects.
Human immunology - 1 Feb 2016
Oboshi Wataru, Watanabe Toru, Matsuyama Yuumi, Kobara Ayana, Yukimasa Nobuyasu, Ueno Ichiro, Aki Kensaku, Tada Tomoki, Hosoi Eiji
Abstract excerpt
NK cells express the CD16 (FcγRIIIa) receptor, which mediates antibody-dependent cellular cytotoxicity (ADCC), on their cell surface. Therefore, ADCC activity may be influenced by qualitative or quantitative changes in the CD16 molecule on NK cells. Responses to NK cell-mediated ADCC have been shown to depend on single nucleotide polymorphisms (SNPs) at FcγRIIIa amino acid position 158. However, a consensus has...
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