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Article

The V158F polymorphism in human FcγRIIIa/CD16a defines opposing receptor responses when interacting with soluble immune complexes.

Journal of immunology (Baltimore, Md. : 1950) - 7 Jun 2026

Eckert Nicolas Manuel, Kolb Philipp, Lerch Florian, Voll Reinhard Edmund, Hofmann Maike, Puchhammer-Stöckl Elisabeth, Vietzen Hannes, Falcone Valeria, Hengel Hartmut

Abstract excerpt

The V158F polymorphism found in the human Fc receptor CD16a (also known as FcγRIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F is known to influence the IgG affinity, and thereby triggering of the CD16a receptor expressed on various immune cells. In contrast to CD16 triggering by opsonized IgG, the mechanistic details of its interaction with soluble circulating IgG...

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Share to Antigen-Antibody Complex
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 42362488
DOI: 10.1093/jimmun/vkag160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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