Article
Frequency analysis of the g.7081T>G/A and g.10872T>G polymorphisms in the FCGR3A gene (CD16A) using nested PCR and their functional specific effects.
Genes and immunity - 1 Jan 2019
Pérez-Romero Camilo Andrés, Sánchez Isaura Pilar, Naranjo-Piedrahita Laura, Orrego-Arango Julio Cesar, Muskus-López Carlos Enrique, Rojas-Montoya Winston, Franco Restrepo Jose Luis, Trujillo-Vargas Claudia Milena
Abstract excerpt
Polymorphic variants p.66L>R/H (g.7081T>G/A; rs10127939) and p.176F>V (g.10872T>G; rs396991) in FCGR3A (CD16A) have been associated with defects in cytotoxic function of natural killer (NK) cells in humans. Genotyping of these variants in genomic DNA has been ambiguous because of high degree of homology between FCGR3A and FCGR3B. We designed a strategy to genotype these polymorphisms and to evaluate their effects...
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