Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules.

PloS one - 1 Jan 2015

Rother Sascha, Hundrieser Joachim, Pokoyski Claudia, Kollrich Sonja, Borns Katja, Blasczyk Rainer, Poehnert Daniel, Klempnauer Jürgen, Schwinzer Reinhard

Abstract excerpt

Studying genetic diversity of immunologically relevant molecules can improve our knowledge on their functional spectrum in normal immune responses and may also uncover a possible role of different variants in diseases. We characterized the c.503T>C polymorphism in the human KLRB1 gene (Killer cell lectin-like receptor, subfamily B, member 1) coding for the cell surface receptor CD161. CD161 is expressed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to HEK293 Cells

Share to Killer Cells, Natural

Share to Lymphocyte Activation

Share to Lymphocyte Count

Share to Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 26309225
DOI: 10.1371/journal.pone.0135682
PMCID: PMC4550425

Genes

KLRB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules.PMID 26309225Read ↗

Molecular basis for LLT1 protein recognition by human CD161 protein (NKRP1A/KLRB1).Semantic proximity Read ↗

The killer cell lectin-like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation.Semantic proximity Read ↗

The V158F polymorphism in human FcγRIIIa/CD16a defines opposing receptor responses when interacting with soluble immune complexes.Semantic proximity Read ↗

Frequency analysis of the g.7081T>G/A and g.10872T>G polymorphisms in the FCGR3A gene (CD16A) using nested PCR and their functional specific effects.Semantic proximity Read ↗

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.Semantic proximity Read ↗

Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphismSemantic proximity Read ↗

Analysis of FCGR3A-p.176Val variants in women with recurrent pregnancy loss and the association with CD16a expression and anti-HLA antibody status.Semantic proximity Read ↗

LILRB1 polymorphism and surface phenotypes of natural killer cells.Semantic proximity Read ↗

Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage.Semantic proximity Read ↗

A 17q12 allele is associated with altered NK cell subsets and function.Semantic proximity Read ↗

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.Semantic proximity Read ↗

Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.