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Article

Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage.

Current molecular medicine - 1 Jan 2024

Canossi Angelica, Aureli Anna, Del Beato Tiziana, Novelli Giorgio, Buonomo Oreste, Rossi Piero, Venditti Adriano, Papola Franco, Sconocchia Giuseppe

Abstract excerpt

BACKGROUND: The identification in breast cancer (BC) of novel genetic biomarkers regulating natural killer (NK) cell function, including the HLA, KIR, and CD16A (FCGR3A), may be still a challenge. OBJECTIVE: We aimed to evaluate whether the combined effect of these polymorphisms has an impact on BC susceptibility and progression. METHODS: 47 BC Italian patients and healthy individuals (39 females and 66 males/...

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PMID: 37461339
DOI: 10.2174/1566524023666230717162458

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