Article
CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy.
Oncotarget - 18 Apr 2017
Ulasov Ilya V, Kaverina Natalya V, Ghosh Dhimankrishna, Baryshnikova Marya A, Kadagidze Zaira G, Karseladze Apollon I, Baryshnikov Anatoly Y, Cobbs Charles S
Abstract excerpt
Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate...
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