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Article

CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity

9 May 2021

Abstract excerpt

Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of GSCs and as a mediator of chemoresistance. Mechanistically, CD109...

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PMID: 33986188
DOI: 10.1172/jci.insight.141486

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