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Oncolytic herpes simplex viruses for the treatment of glioma and targeting glioblastoma stem-like cells

31 May 2023

Abstract excerpt

Glioblastoma (GBM) is one of the most lethal cancers, having a poor prognosis and a median survival of only about 15 months with standard treatment (surgery, radiation, and chemotherapy), which has not been significantly extended in decades. GBM demonstrates remarkable cellular heterogeneity, with glioblastoma stem-like cells (GSCs) at the apex. GSCs are a subpopulation of GBM cells that possess the ability to...

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PMID: 37325516
DOI: 10.3389/fcimb.2023.1206111

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