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Article

Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors.

Cancer research - 15 Apr 2009

Wakimoto Hiroaki, Kesari Santosh, Farrell Christopher J, Curry William T, Zaupa Cecile, Aghi Manish, Kuroda Toshihiko, Stemmer-Rachamimov Anat, Shah Khalid, Liu Ta-Chiang, Jeyaretna Deva S, Debasitis Jason, Pruszak Jan, Martuza Robert L, Rabkin Samuel D

Abstract excerpt

Glioblastoma, the most malignant type of primary brain tumor, is one of the solid cancers where cancer stem cells have been isolated, and studies have suggested resistance of those cells to chemotherapy and radiotherapy. Here, we report the establishment of CSC-enriched cultures derived from human glioblastoma specimens. They grew as neurospheres in serum-free medium with epidermal growth factor and fibroblast...

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Identifiers

PMID: 19351838
DOI: 10.1158/0008-5472.CAN-08-3886
PMCID: PMC2785462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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