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Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity

3 May 2016

Abstract excerpt

The cancer stem cells (CSCs) of glioblastoma multiforme (GBM), a grade IV astrocytoma, have been enriched by the expressed marker CD133. However, recent studies have shown that CD133(-) cells also possess tumor-initiating potential. By analysis of gangliosides on various cells, we show that ganglioside D3 (GD3) is overexpressed on eight neurospheres and tumor cells; in combination with CD133, the sorted cells...

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PMID: 27143722
DOI: 10.1073/pnas.1604721113

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