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Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma

1 Aug 2015

Abstract excerpt

Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties. Here, we show how HCMV IEs are preferentially expressed in glioma stem-like cells (GSC), where they colocalize with the other GBM stemness markers, CD133, Nestin, and Sox2. In...

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PMID: 26239477
DOI: 10.1158/0008-5472.can-14-3307

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