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Article

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2.

Oncogene - 23 Jul 2015

Lopez-Bertoni H, Lal B, Li A, Caplan M, Guerrero-Cázares H, Eberhart C G, Quiñones-Hinojosa A, Glas M, Scheffler B, Laterra J, Li Y

Abstract excerpt

Cancer stem-like cells represent poorly differentiated multipotent tumor-propagating cells that contribute disproportionately to therapeutic resistance and tumor recurrence. Transcriptional mechanisms that control the phenotypic conversion of tumor cells lacking tumor-propagating potential to tumor-propagating stem-like cells remain obscure. Here we show that the reprogramming transcription factors Oct4 and Sox2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25328136
DOI: 10.1038/onc.2014.334
PMCID: PMC4404208

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